⑴ 求高人解答富馬酸二甲酯的執行標准，安全說明書(MSDS)及生產工藝
富馬酸二甲酯的執行標准： 1、「DMF」指化學品富馬酸二甲酯，IUPAC（國際純化學與應用化學聯盟）名稱為Dimethyl （E）-butenedioate，CAS（化學物質登記號）編號：624-49-7，EINECS（歐洲現有商用化學物質目錄信息系統）編號：210-849-0。 2、「產品」指第2001/95/EC號指令第2（a）條中定義的任何產品； 3、「含有富馬酸二甲酯的產品」指如下產品或產品零件： （i）聲明了富馬酸二甲酯的存在率，如在一個或多個小袋子上；或 （ii）富馬酸二甲酯的濃度大於每公斤該產品或產品零件重量0.1毫克； 4、「投放市場」指第一次在共同體市場銷售； 5、「在市場上銷售」指在商業活動過程中提供用於在共同體市場上經銷、消費或使用，不管是有償還是無償。 國家皮革質量監督檢驗中心（浙江）於2008年開始重點前瞻性研究應對這一技術性貿易措施的技術，於2008年下半年已經率先提供這一測試技術服務。2008年以來，歐洲相繼發生中國皮革產品使用含DMF防霉劑疑致消費者過敏事件，主要涉及的產品包括椅子和鞋，2008年底法國、西班牙就禁止含有DMF的椅子進口，上月歐盟國家通過了禁止進口DMF的決定。
MSDS 不知道你是想要什麼版本的MSDS， 一般要英文的多 ， 就給你你個英文吧 ， **** MATERIAL SAFETY DATA SHEET ****
N,N-Dimethylformamide, for HPLC
**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: N,N-Dimethylformamide, for HPLC
Catalog Numbers:
27960-0000, 27960-0010, 27960-0025
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+-----------+---------------+
| CAS# | Chemical Name | % | EINECS# |Haz Symbols| Risk Phrases |
|----------------|--------------------------------------|----------|-----------|-----------|---------------+
| 68-12-2 |N,N-Dimethylformamide, for HPLC | | 200-679-5 |||
+----------------+--------------------------------------+----------+-----------+-----------+---------------+
Hazard Symbols: T
Risk Phrases: 20/21 36
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Harmful by inhalation and in contact with skin. Irritating to eyes.
May cause harm to the unborn child.Toxic.Combustible liquid.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Substance is rapidly absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause kidney damage. May cause liver damage.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation. May
cause effects similar to those described for ingestion.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Ince vomiting. If victim is conscious and alert, give 2-4 cupfuls
of milk or water. Never give anything by mouth to an unconscious
person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Will burn if involved in a fire.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use foam, dry
chemical, or carbon dioxide.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Do not flush into a sewer. Remove
all sources of ignition.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Use only in a well-ventilated area. Use spark-proof tools and
explosion proof equipment. Avoid breathing st, vapor, mist, or
gas. Avoid contact with skin and eyes. Use only in a chemical fume
hood.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower.
Personal Protective Equipment
Eyes:
Wear safety glasses and chemical goggles if splashing
is possible.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Always use
a NIOSH or European Standard EN 149 approved
respirator when necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Clear liquid
Color: APHA: 5 max
Odor: amine-like - faint odor
pH: Not available.
Vapor Pressure: 4.9 mbar @ 20 C
Viscosity: 0.8 mPa s 20 deg C
Boiling Point: 153 deg C @ 760.00mm Hg
Freezing/Melting Point: -61 deg C
Autoignition Temperature: 445 deg C ( 833.00 deg F)
Flash Point: 58 deg C ( 136.40 deg F)
Explosion Limits, lower: 2.20 vol %
Explosion Limits, upper: 16.00 vol %
Decomposition Temperature:
Solubility in water: soluble in water
Specific Gravity/Density: .9450g/cm3
Molecular Formula: HCON(CH3)2
Molecular Weight: 73.09
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable.
Conditions to Avoid:
Stable., incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Oxidizing agents, recing agents, acids, halogenated agents,
nitrates, chloroformates.
Hazardous Decomposition Procts:
Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 68-12-2: LQ2100000
LD50/LC50:
CAS# 68-12-2: Inhalation, mouse: LC50 = 9400 mg/m3/2H; Inhalation,
rat: LC50 = 3421 ppm/1H; Inhalation, rat: LC50 = 3421 ppm/3H;
Inhalation, rat: LC50 = 1948 ppm/4H; Oral, mouse: LD50 = 2900 mg/kg;
Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2800 mg/kg; Skin,
rabbit: LD50 = 4720 mg/kg; Skin, rat: LD50 = >3.2 gm/kg.
Skin, rat: LD50 = 5 gm/kg
Carcinogenicity:
N,N-Dimethylformamide, for HPLC -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Damage to fish: Gold oland test: 18 hrs LC50: 500 mg/l
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing Group: III
IMO
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing Group: III
RID/ADR
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing group: III
USA RQ:CAS# 68-12-2: 100 lb final RQ; 45.4 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 61 May cause harm to the unborn child.
R 20/21 Harmful by inhalation and in contact with
skin.
R 36 Irritating to eyes.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 68-12-2: 1
United Kingdom Occupational Exposure Limits
CAS# 68-12-2: OES-United Kingdom, TWA 10 ppm TWA; 30 mg/m3 TWA
CAS# 68-12-2: OES-United Kingdom, STEL 20 ppm STEL; 61 mg/m3 STEL
United Kingdom Maximum Exposure Limits
Canada
CAS# 68-12-2 is listed on Canada's DSL List.
CAS# 68-12-2 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 68-12-2: OEL-AUSTRALIA:TWA 10 ppm (30 mg/m3);Skin
OEL-BELGIUM:TWA 10 ppm (30 mg/m3);Skin
OEL-CZECHOSLOVAKIA:TWA 30 mg/m3;STEL 60 mg/m3
OEL-DENMARK:TWA 10 ppm (30 mg/m3);Skin
OEL-FINLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3);Skin
OEL-FRANCE:TWA 10 ppm (30 mg/m3);Skin
OEL-GERMANY:TWA 20 ppm (60 mg/m3);Skin
OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin
OEL-JAPAN:TWA 10 ppm (30 mg/m3);Skin
OEL-THE NETHERLANDS:TWA 10 ppm (30 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 10 ppm (30 mg/m3);Skin
OEL-POLAND:TWA 10 mg/m3
OEL-RUSSIA:TWA 10 ppm;STEL 10 mg/m3;Skin
OEL-SWEDEN:TWA 10 ppm (30 mg/m3);STEL 15 ppm (45 mg/m3);Skin
OEL-SWITZERLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm;Skin
OEL-TURKEY:TWA 10 ppm (30 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);STEL 20 ppm;Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 68-12-2 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 7/16/1996 Revision #0 Date: Original.
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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生產工藝：
1、硫酸催化合成DMF 不含富馬酸二甲酯的乾燥劑 硫酸作為催化劑是經典的合成法,產品收率可以達到92%〔4，8，9〕，雖然這種方法簡單收率高，但是，由於硫酸的腐蝕性，會引起副反應，且有三廢污染等缺點。 2、對甲苯磺酸催化合成DMF 甲苯磺酸作為催化劑合成DMF，產品產率為67%左右。對甲苯磺酸是一種有機酸，雖然其對設備的腐蝕性和三廢比較少、不易引起副反應、產品色澤好、價廉易得、易於保存運輸和使用，用量少，活性高，但是產率比較低等缺點。 3、樹脂催化合成DMF 強酸性陽離子交換樹脂早在20世紀50年代就開始用於一些酯化反應中，生成的酯色度低，後處理方便，可重復使用，對設備無腐蝕性，不產生三廢，極有工業使用價值。使用強酸性離子交換樹脂作為催化劑合成DMF，其產率可達到91.4%。 4、固體超強酸催化合成DMF 固體超強酸催化合成富馬酸二甲酯超強酸是酸強度比100%硫酸更強的酸。固體超強酸具有不腐蝕設備、不污染環境、不怕水、耐高溫、反應活性高、選擇性好、製造容易、在反應體系中易分離、不易中毒等優點,同時可以重復使用,因而具有一定的工業應用價值。 5、氯化鐵催化合成DMF 譜尼測試提供富馬酸二甲酯檢測服務 結晶氯化鐵催化合成富馬酸二甲酯結晶氯化鐵（FeCI3•6H2O）是一種價廉易得的化合物，利用它催化合成富馬酸二甲酯，腐蝕小，三廢污染較輕，操作方便，有一定應用價值,其有利應用條件是：當催化劑0.8g，富馬酸58g，甲醇20ml，，即摩爾比為0.06∶1∶10，迴流4h，得白色結晶產品，收率達61.7%〔13〕。 6、雜多酸催化合成DMF 雜多酸是由兩種以上無機含氧酸縮合而成的多元酸,它不僅具有多元酸和多電子還原能力,而且其酸性和氫化還原性可以通過變換組成元素在很大范圍內系統地調節。它對許多反應具有高的催化活性和選擇性,並且不揮發,對熱穩定、污染少、可以大大減輕對設備的腐蝕,能夠再生和重復使用。 7、稀土化合物催化合成DMF 稀土化合物是我國易得、資源豐富的化合物,開發稀土化合物的利用很有經濟價值。李曉莉等利用三氧化二釹(Nd2O3)催化合成了富馬酸二甲酯，當15g富馬酸,30ml甲醇，三氧化二釹用量為3%，迴流4h，得產品收率90%〔15〕。 8、BF3•(C2H5)2O催化合成DMF 三氟化硼(BF3)是強的電子接受體，強的Lewis酸，能夠與供電子的羧酸中羧基形成復合物，使羧基中的碳帶更多的正電荷，但BF3是氣體，故催化酯化反應的進行，常利用其與醇或醛等形成釒羊鹽而使用。
看看多來點分吧 ， hehe 多多益善啊 嘿嘿